Bitter compounds are far more than just a bitter taste—they activate the body's own processes that influence digestion (1), appetite (3), and metabolism (2). Scientific studies show how these plant compounds strengthen the microbiome, support the liver, and promote satiety (Richter et al., 2022). Discover how Daily Bitter brings this ancient plant power into your routine in a modern, everyday form.
What are bitter substances?
Bitter compounds are natural secondary plant substances found in artichokes, gentian, wormwood, and yarrow, among others. In nature, they serve as a protective mechanism against herbivores, but in the human body, they exert far-reaching physiological effects (Wooding et al., 2021).
Already upon contact with the bitter receptors (TAS2Rs) on the tongue, signals are triggered that can influence not only the sense of taste, but also digestive processes and even the immune system (Richter et al., 2022; Schling, 2019).
In short: bitter substances are a natural aid to diet control.
How do bitter substances work in the body?
Influence on digestion & hormones
Bitter substances stimulate saliva and gastric juice production. Through hormonal signaling pathways, they promote the release of digestive hormones such as GLP-1, CCK, and PYY (Sternini & Rozengurt, 2025), which improves protein digestion and promotes satiety. At the same time, bitter substances activate receptors in the intestinal muscles, stimulating peristalsis—the natural intestinal movement. 1, 2 (Jeruzal-Świątecka et al., 2020).
In short: bitter substances prepare the body for digestion.
The effect on microbiome & immune system
Bitter substances stimulate the production of bile in the intestine. This contributes to fat digestion and can create an environment in the intestine that supports the natural digestive process (1,2). A well-functioning digestive tract, in turn, is an important foundation for general well-being and the microbiome. A balanced microbiome, in turn, is closely linked to a strong immune system, as a large proportion of immune cells are located in the intestine. Bitter substances therefore promote intestinal culture diversity and strengthen the intestinal barrier, thus contributing to balanced intestinal activity. (1,2).
Are bitter substances good for the liver and gallbladder?
Bitter compounds promote the secretion of bile from the liver and stimulate gallbladder contraction. This improves fat digestion and can relieve bloating or a feeling of fullness (Richter et al., 2022). Some bitter compounds also possess liver-protective and antifibrotic properties by regulating inflammatory processes (Saugspier et al., 2012).
Metabolism stimulation and natural appetite regulation
By activating TAS2R receptors, bitter compounds influence metabolism and the release of the appetite hormone ghrelin, which can lead to reduced food intake (Schiano et al., 2024; Deloose et al., 2018). At the same time, they promote insulin secretion via GLP-1 (D'Urso & Drago, 2021). Thus, bitter compounds can be considered natural appetite suppressants and offer valuable support for weight loss.
Daily Bitter - the modern bitter formula
After understanding the scientific background of bitter substances, the question often arises: How can they be easily incorporated into everyday life? This is precisely where Daily Bitter comes in: It combines 11 proven plant extracts such as gentian, artichoke, dandelion root, and licorice root in alcohol-free drop form with apple cider vinegar. This modern formulation allows for easy daily use, even for sensitive individuals. The mild formula, in particular, makes Daily Bitter suitable for beginners.
Application & intake
• Ideally 15–30 minutes before meals
• Take directly on the tongue or with a teaspoon
• 2–3 times daily
• Do not combine with sugary foods, as this may weaken the effect (Tagliamonte et al., 2025)
Who are bitter substances suitable for?
Bitter substances are suitable for people with digestive problems such as bloating, feeling of fullness or cravings, for people with a sluggish metabolism or slightly elevated blood sugar, and generally for anyone who wants to be more conscious about their diet and support their microbiome (Chou, 2021; Rezaie et al., 2021).
Which foods contain bitter substances?
Bitter compounds are found primarily in vegetables and herbs. Sources include arugula, chicory, Brussels sprouts, kale, grapefruit, and broccoli. Beverages can also contain bitter compounds. These include green tea, black tea, and coffee. Finally, some medicinal plants are also rich in bitter compounds: gentian, wormwood, centaury, hops, and dandelion. These foods can be easily integrated into everyday life and provide a natural source of bitter compounds (Yan & Tong, 2022; Qiao et al., 2024).
FAQ on bitter substances and Daily Bitter
When and for how long can I take bitters?
Bitters can be taken daily and long-term. With regular use, the body can become accustomed to the bitter taste, and the effects build up over weeks (Elechi-Amadi et al., 2020). Contained plants such as licorice root then support the function of the digestive system, helping to relieve gastrointestinal discomfort and achieve greater digestive comfort (1). Dandelion root also supports digestion and helps maintain normal liver function (2).
Are there any side effects to bitter substances?
In isolated cases: heartburn or nausea. If you have pre-existing stomach problems or are pregnant or breastfeeding, use only after consulting a medical professional.
Is Daily Bitter really alcohol-free?
Yes, Daily Bitter is based on apple cider vinegar—no alcohol. Ideal for sensitive individuals or those who want to avoid alcohol.
Conclusion: Bitter substances as natural support
Bitter substances are more than just a taste sensation—they activate the body's own receptors, which play a key role in digestion, appetite regulation, metabolism, and immune function. Studies demonstrate their positive effects on the liver, microbiome, and hormonal balance.
With Daily Bitter, you can easily integrate this plant power into your daily routine – alcohol-free, vegan, and effective.
(1) Liquorice root supports the function of the digestive system, helps eliminate gastrointestinal discomfort, and provides digestive comfort.*
(2) Dandelion root to support digestion and helps maintain normal liver function, promote digestion, and detoxify the body.*
(3) Centaury to support a normal appetite.*
*This botanical ingredient is currently under review (“on hold”) under EU Regulation (EC) No. 1924/2006 (Health Claims Regulation).
